补肾活血法干预遗传性肾病肾功能损伤1例病例报道

韩阳; 张勉之

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补肾活血法干预遗传性肾病肾功能损伤1例病例报道

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补肾活血法干预遗传性肾病肾功能损伤1例病例报道
A Case Report of Kidney Function Injury in Hereditary Nephropathy Treated by Bushen Huoxue Recipe
1.天津市中医药研究院附属医院肾病科，天津 300120
DOI：

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韩阳, 张勉之. 补肾活血法干预遗传性肾病肾功能损伤1例病例报道[DB/OL].（2023-10-26）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052905&Fpath=home&index=0

HAN Yang, ZHANG Mianzhi. A Case Report of Kidney Function Injury in Hereditary Nephropathy Treated by Bushen Huoxue Recipe[DB/OL].（2023-10-26）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052905&Fpath=home&index=0
韩阳, 张勉之. 补肾活血法干预遗传性肾病肾功能损伤1例病例报道[DB/OL].（2023-10-26）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052905&Fpath=home&index=0 DOI：

HAN Yang, ZHANG Mianzhi. A Case Report of Kidney Function Injury in Hereditary Nephropathy Treated by Bushen Huoxue Recipe[DB/OL].（2023-10-26）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052905&Fpath=home&index=0 DOI：

摘要

病史摘要,2,患者主因“乏力伴镜下血尿15年，血肌酐升高3月”于门诊就诊，既往肾活检诊为系膜增生性肾炎（未行电镜检查），患者此次因血肌酐升高就诊，门诊考虑患者慢性肾功能不全，予补肾活血法中药汤剂及院内制剂治疗后，血肌酐下降至正常范围，后入院行重复肾活检，考虑遗传性肾病，后期随访患者尿常规转阴，肾功能正常，OmniSeek全外显子组检测报告提示：受检者样本检测到与表型相关的基因变异c.1652_1653delinsAA，证实了复检的肾活检结果。中医诊断　虚劳证候诊断　肾虚血瘀证西医诊断　慢性肾脏病2期；遗传性肾病（Alport综合征？、薄基底膜肾病？）；高尿酸血症；高血压病。干预措施　中药汤剂：补肾活血方（自拟），新肾康宁胶囊、肾衰排毒胶囊（院内制剂）转归　临床治愈

Abstract

Summary of case history,　The patient's main reason was "fatigue accompanied by microscopic hematuria for 15 years, and blood creatinine increased for 3 months". The previous renal biopsy was diagnosed as mesangial proliferative nephritis (no electron microscopic examination was performed). The patient's blood creatinine increased this time. The outpatient considered the patient's chronic renal insufficiency. After the treatment with Chinese medicine decoction of Tonifying the kidney and activating blood circulation and hospital preparations, the blood creatinine decreased to the normal range. After that, the patient was admitted to the hospital for repeated renal biopsy to consider hereditary nephropathy, In the later follow-up, the urine routine of the patients turned negative and the renal function was normal. The omniseek whole exome test report suggested that the gene variant c.1652 related to the phenotype was detected in the samples of the subjects_ 1653delinsaa, confirming the renal biopsy results of the re examination.,TCM diagnosis,　asthenic fatigue disease,Syndrome diagnosis,　kidney deficiency and blood stasis syndrome,Western medicine diagnosis,　chronic kidney disease (stage 2);hereditary nephropathy (alport syndrome? thin basement membrane nephropathy?);hyperuricemia;hypertension.,Therapeutic methods,　traditional Chinese medicine decoction:bushen huoxue recipe, xinshenkangning capsule and Shenshuai Paidu capsule (preparation in the hospital),Clinical outcomes,　Clinical cure.

关键词

遗传性肾病补肾活血法重复肾活检

Keywords

hereditary nephropathykidney tonifying and blood activating methodrepeat kidney biopsy

references

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