Summary of case history,　The patient seek medical advice for "abdominal distension, fatigue and edema of both lower limbs for 1 week". In January 2021, abdominal distension and fatigue appeared after fatigue, accompanied by edema of both lower limbs, and there was no relief after rest. The patient has a history of chronic hepatitis B for more than 40 years, during which no regular diagnosis and treatment were made. Previous history: deny other chronic history. Personal history: denied drinking history. Family history: father died of liver cancer. Physical examination: Face with liver disease, mild yellow staining of sclera, slight swelling of abdomen, no tenderness and rebound pain in the whole abdomen, no liver touch, large spleen, about 3 horizontal fingers under the ribs. Percussion pain in the liver area was negative, Murphy sign (-), mobile voiced sound was positive, and both lower limbs were edema. Tongue pulse: the tongue is dark red, tongue coating is white and thick, and the pulse is deep and thin. Auxiliary examination: (January 25, 2019) liver function: ALT 44.2U/L, AST 60.6U/L, ALB 35.8g /L. Blood routine: WBC 4.06*10,9,/L, RBC 4.02*10,12,/L, HgB 134g/L, PLT 54*10,9,/L. Hemagglutination: PTA 71%. HBVDNA 1.05E+006IU/ml. Five items of hepatitis B: HBsAg, HBeAb, and HBcAb (+). AFP 14.2ng/mL. Liver stiffness value E 75Kpa. Abdominal B-ultrasound: Diffuse liver lesions; Splenomegaly (13.7*4.3cm); Ascites (about 7.5cm deep in the lower abdomen).,TCM diagnosis,　Tympanite-Qi deficiency induced blood stasis pattern, Spleen deficiency with water retention pattern, water retention pattern,Western medicine diagnosis,　HBeAg negative decompensated hepatitis B cirrhosis; Splenomegaly; ascites,Therapeutic methods,　①Traditional Chinese medicine treatment: Invigorating Qi and activating blood circulation, invigorating spleen and eliminating dampness, benefiting water and reducing swelling. The prescription is as follows: raw Astragalus membranaceus 60g, Angelica sinensis 15g, Eupatorium adenophorum 15g, vinegar turtle shell 15g (decocted first), white peony 10g, vinegar chicken inner gold 10g, Poria cocos skin 30g, winter melon skin 30g, zucchini 15g, Fangji 15g, sedge 10g, Alisma orientalis 20g, Yinchen 10g, Scutellaria baicalensis 10g, big belly skin 15g, Amomum villosum 6G (later), white nutmeg 10g, cinnamon branch 10g, fried betel nut 10g, Magnolia 10g, Twice a day, warm drinking. ②Western medicine treatment: 1. Antiviral: entecavir 0.5mg QD Po 2. Liver protection: silybin capsule 140mg TID Po 3. Diuretic: spironolactone 40mg bid + furosemide 20mg QD Po.,Clinical outcomes,　After about 10 months of treatment with combination of Chinese and Western medicine, the symptoms of abdominal distension, fatigue, poor appetite and fear of cold disappeared, and the abdominal swelling disappeared. Liver function and hemagglutination were normal. The abdomen disappeared by ultrasonic examination, from 6.4 to 0mm. Liver stiffness value E changed from 75.8 to 8.0kpa.