Summary of case history,　The female patient MA, 60 years olds, who was mainly due for "intermittent depression, loss of interest, and exciting, irritability for 3 years, and depression with suicidal idea for 2 weeks". Three years ago, the patient developed intermittent depression, loss of interest, social retreat, and exciting, irritability because of work and life pressure, and was diagnosed with bipolar disorder in Peking University Sixth Hospital, treated with Quetiapine Fumarate, the mood plateaued, then stoped medicine by herself, the illness repeated, excitement and depression alternatively appeared, after frequent replace mental medication treatment plan, mood symptoms without obvious improvement, two weeks ago frequently appeared depression and suicidal idea , then seek Chinese medicine treatment.Symptoms and signs: Depression, suicidal idea, irritability, dizziness, chest tightness, shortness of breath, poor sleep, anorexia, chilly, occasionally hot sweating, stool is thin. Tongue light body fat has tooth marks, moss thick slightly yellow greasy, pulse heavy slightly fine. The teeth-marked tongue is plump, with light yellow and greasy fur, and deep fine rapid pulse.,TCM diagnosis,　Depression disease with combination of phlegm and heat, stagnation of liver-QI, insufficiency of the spleen, Sukra prameha.,Western medicine diagnosis,　1.Acute phase of bipolar depression; 2.Generalized anxiety disorder.,Therapeutic methods,　Traditional Chinese medicine uses the method of removing heat-phlegm, soothing liver, strengthening and warming the kidney and uses modified Wendantang for treatment. Western medicine gave the mood stabilizer Lamotrigine combined with the second-generation antipsychotic Quetiapine and the selective serotonin reabsorption inhibitor Sertraline.,Clinical outcomes,　The patient's mood plateaued, no obvious symptoms of physical discomfort, Sertraline was stopped, and the quality of life was significantly improved.