Summary of case history,　The patient, a 65-year-old man, he sought care at the hospital on January 19,2021 for "Foam urine appeared for 5 years, aggravated with both eyelids and lower extremities edema for 1 week". Five years ago, the patient had no obvious cause of increased foam in the urine, sudden edema of both eyelids and lower extremities, no frequent urination, urgent urination and pain, no gross hematuria, no aversion to cold or fever, no rash and joint pain. The patient went to the local hospital, in order to improve and perfect the relevant examination, and the renal puncture biopsy was clearly diagnosed as "stage I membranous nephropathy", and he was treated with "prednisolone tablets (starting from 60 mg) with cyclophosphamide (8 g)". After that, the prednisolone tablets were gradually reduced to 1 tablet every day, and the patient stated that proteinuria was reduced to normal, both eyelids and lower extremities edema disappeared. In May 2020, the patient went to the orthopedic department of our hospital for "bilateral femoral head necrosis". Due to albumin 30.0 g/L,he was transferred to the nephrology department. The treatment plan was adjusted as follows:tacrolimus 1mg bid. Other treatments continued to use atorvastatin calcium tablets 20 mg qd, clopidogrel tablets 75mg qd were used for anti-platelet . The 24-hour urinary protein quantification during hospitalization was 552 mg /24 h, 1989 mg/24 h, 2354 mg/24 h and 1161 mg/24 h. After discharge. the patient took medication regularly, and after the plasma albumin and urinary protein returned to normal, bilateral total hip arthroplasty was performed. thereafter,the patient's condition was recurred, in the past of week, there was an increase of urine foam and edema of both lower extremities, and the routine urine examination showed occult blood ±;protein 3+; 24-hour urinary protein quantity: 2312 mg/24 h. In order to further seek treatment of TCM ,he came to our consulting room. Symptoms: conscious mind, fair spirit,a lof of foam in the urine, no obvious abnormalities in urine volume and color. diet and sleep are fair, and defecate regularly. Dark red tongue , white thick greasy fur and thready and slippery pulse.,TCM diagnosis,　Renal edema (hypofunction of both the spleen and the kidney , deficiency of both qi and yin,obstruction of both damp and blood stasis),Western medicine diagnosis,　Membranous Nephropathy Stage I .,Therapeutic methods,　Traditional Chinese medicine treatment:Complementing and fixing the essence, activiting blood and removing stasis. The self-designed Qidi Gushen recipe. ,Clinical outcomes,　Clinical cure