Objective:,2,To explore the academic thought of Professor LI Guixian, an academic veteran teacher of traditional Chinese medicine, in the treatment of Yin deficiency and being afraid of cold.,Methods:,2,The pathogenesis of Yin deficiency and cold was deeply analyzed from the theory of internal hyperactivity, and the academic thought of Professor LI Guixian was discussed on the basis of classical works of previous generations combined with clinical medical cases.,Results:,2,Professor LI Guixian, based on many years of clinical experience, has proposed that Yin deficiency and cold sydnrome in the pathogenesis of the disease is not separated from the spleen and kidney, the Ying-Wei and the essence of Qi, which conforms to the characteristics of the occurrence and outcome of the disease, and the treatment of filling the excess and marrow, nourishing the spleen and kidney Yin and camping heat, regulating Qi and Wei treatment. The experience of this syndrome has a good clinical effect.,Conclusion:,2,Professor LI Guixian's academic thought and successful experience on Yin deficiency and being afraid of cold are worthy of popularizing. It is of great significance for doctors to identify the symptoms of true and false symptoms in clinical practice.