Medical history abstract,　The patient went to see the doctor due to lack of power and anorexia for more than 3 months, accompanied by edema of both lower limbs, and had been checked for abnormal renal function. Post-hospital examination: urine routine test: pro2+, RBC464.4/ul, 24 h urine protein quantitative test: 3.16 g, blood routine test: RBC2.83×1012/L, Hb83 g/L, renal function: BUN12.27 mmo1/L, Scr374.1 umol/L, eGFR13.63 ml/min, UA146 umol/L. TCO2:16.7mmol/L。 After treatment based on syndrome differentiation of traditional Chinese medicine, combined with retention enema of traditional Chinese medicine and symptomatic treatment of western medicine, blood creatinine gradually decreased and renal function returned to normal, reversing the progress of the patient's condition.,TCM diagnosis,　chronic renal failure (spleen and kidney deficiency with damp-heat syndrome),Western medicine diagnosis,　chronic kidney disease , renal anemia, metabolic acidosis; Chronic glomerulonephritis?,Intervention measures,　Traditional Chinese medicine is given orally to invigorate the spleen and kidney, clear heat and remove dampness, and the retention enema of Jiedu Jiezhuo granules, a hospital preparation, is combined to strengthen the function of clearing heat and removing turbidity; Combined with western medicine erythropoietin (Epo), polysaccharide iron, folic acid, etc. to correct anemia, and sodium bicarbonate (SB) to correct acidosis. Regular reexamination and re-diagnosis every four weeks, Chinese medicine plus or minus as well as western medicine for symptomatic auxiliary treatment.,Curative outcome,　The patient was diagnosed as CKD, and was treated with TCM syndrome differentiation and western medicine to correct anemia, acidosis and other symptomatic treatments. For nearly 3 years, serum creatinine continued to decline until the renal function returned to normal. Follow-up for nearly one and a half years showed that renal function remained normal.