A young male,named Sun, who present spontaneous because of "intermittent diarrhea for more than 34 years, aggravated for 5 days,with eosinophilia". By a series of tests inlcuding peripheral blood cell count, leukocyte classification, biochemical items, chest CT, bone marrow morphology, flow immunotyping, fusion gene, FISH, chromosomal, bone marrow pathology, colonoscopy and histopathology, he was clearly diagnosed hypereosinophilia in Western medicine. Due to the cause of this disease has not been completely determined, there is no specific treatment plans, the main treatment indication is the involvements and dysfunction of important organs generally. At present, this patient has no target organ damage, so there is no special treatments for him in western medicine for the time being. According to symptoms that the patient has diarrhea repeatedly for many years, with thin stool, fearing of cold and wind, the diarrhea becomes worse when meeting cold wind or cold food, and the abdominal pain relieved by warm. With the combination of four diagnostic methods, he was diagnosed diarrhea belonging to the syndrome of Yang deficiency of spleen and kidney in TCM. Based on the principle of warming the middle energizer to dissipate cold, raising the Qi, and astringent bowel to stop diarrhea, we selected the Fuzi Lizhong Tang and Buzhong Yiqi Tang to treat this patient. After 2 weeks of treatment alone, the patient's diarrhea is significantly relieved. Regular blood routine examinations has showed that eosinophils decreased gradually. After 3 months of follow-up, his diet return to normal, no diarrhea occurred when get cold wind or cold food. The effect was satisfactory.