Summary of case history , The patient Wang, male, 55 years old, was diagnosed with "hypertension" because his blood pressure was 180-220/120 mmHg measured 12 years ago. 10 years ago, it was found that serum creatinine was elevated to 300+umol/l, and renal biopsy indicated hypertensive nephropathy. He had been treated with antihypertensive, traditional Chinese medicine decoction and other treatments. After regular follow-up, serum creatinine gradually increased to 512 μmol/l. and he came to our hospital.Clinical manifestations:Poor spirit, low voice, swollen face, itchy skin, no skin redness, no rash, narcolepsy, normal stool, high urination volume, 2900 ml urine output in 24 hours, nocturia 5-6 times/night, foamy urine, No fever, no profuse sweating, no headache, etc., pale red tongue, thin white coating, heavy pulse and rapid pulse. There was no edema of both lower extremities.,TCM diagnosis ,Chronic renal failure (syndrome of spleen and kidney deficiency with blood stasis and turbidity),Western medicine diagnosis ,①Chronic kidney disease stage 5, secondary hyperparathyroidism. ②Hypertensive nephropathy. ③ Essential hypertension stage 3, high risk.,Therapeutic methods ,Western medicine prescribes lowering blood pressure, improves bone metabolism, and improves renal microcirculation; traditional Chinese medicine provides treatment based on syndrome differentiation, invigorating the spleen and kidney, removing blood stasis and reducing turbidity, and the patient's renal function has improved significantly.,Clinical outcomes ,Significant improvement in renal function