The etiology of premature ovarian failure(POF)is unknown and the treatment is difficult.Professor Luo Songping believes that the pathogenesis of POF is characterized by early deficiency of kidney essence, premature failure of Tiangui, and early deficiency of Chong Ren.From Yin-Yang to distinguish, Yin-essence deficiency is the main factor, and Yang is also inadequate.Invigorating kidney and filling essence is its basic treatment principle.Seeking Yin in Yang and assisting source.At the same time, strengthen the spleen and stomach regulation and tonify, make Qi and blood active, Qi engendering essence, blood essence and Tiangu.POF is chronic deficiency and damage disease, the course of disease is long, remarkable effect is slow.It needed to persevere, mind-body treatment, and paid attention to soothing the liver to relieve depression.Professor LUO Song-ping's clinical experience in the treatment of premature ovarian failure was introduced through a case of spontaneous conception and successful delivery of a patient with POF.