Summary of case history ,Patient Sun, female, 18 years old. The main reason was discontinuous lower limb edema for 2 years. In 2012 due to the continuous double leg edema in Heze Central Hospital, check urine protein quantitative,>,3.5 g of private prosecution diagnosed with nephrotic syndrome, prescribed prednisone for a half months the symptoms ease, after regular reduction of hormone the illness repeatedly, line of renal biopsy pathological types for the" stage Ⅱ membranous nephropathy", prescribed cyclosporine. The edema of the patient was decreased after treatment. Taking medicine regularly for half a year, the quantitative fluctuation of urinary protein in 24 hours was between 1 g and 3 g. In March 2013, cyclosporine was changed to leflunomide in the outpatient department of nephrology of our hospital. One month later, the quantification of urine protein of her at 24 h was 5189 mg, she was hospitalized in the department of nephropathy of our hospital and received sufficient prednisone combined with cyclophosphamide impact therapy. After improvement, she was discharged. The quantity of hormone decreased regularly, and the quantitative fluctuation of urinary protein was about 2000 mg. Later, the disease repeated for several times, and the accumulative amount of cyclophosphamide eventually reached 12 g, the hormone was gradually reduced to the maintenance level and stopped using. On June 9, 2014, she came to our hospital for TCM treatment. At first diagnosis, the patient was conscious, double lower limbs mild edema aggravated in the morning and reduced after activity, little urine volume, light yellow urine, a little foam in the urine, sensation of chill, easy to sweat before going to sleep, especially in the neck, easy to sweat after exercise, especially in the head, polydipsia and drink a lot, diet and sleep are fair, defecate regularly. The tongue is pale and fat, the moss is thin and white, and the pulse is heavy and fine. 24-hour urinary protein was quantified over 1100 mg.,TCM diagnosis ,Edema (qi and yin deficiency, damp heat and blood stasis obstruction).,Western medicine diagnosis ,Membranous Nephropathy Stage Ⅱ.,Therapeutic methods ,TCM treatment: Nourish spleen and kidney, nourish qi and yin, invigorate dampness and promote blood circulation. The self-designed Qidi Gushen recipe.,Clinical outcomes, After taking the medicine for 2 months, the edema basically disappeared, and the effect was not better. On the basis of the unchanged principal prescription, appropriate addition and reduction were made according to the situation of each visit. After taking the medicine for more than 1 year, the edema did not recur, and the symptom of deficiency syndrome basically disappeared.