Analysis of Syndrome Differentiation and Treatment for Mycosis Fungoidesby Pathogenesis Theory of Cancerous Toxin

CHEN Xiaoli; YU Hui; KONG Xiangtu; DAI Xingbin; XU Xiaomeng; NI Haiwen

doi:10.3969/j.issn.1673-7202.2021.17.021

Suggestions

您当前的位置：

首页 >

文章列表页 >

Analysis of Syndrome Differentiation and Treatment for Mycosis Fungoidesby Pathogenesis Theory of Cancerous Toxin

Previous: 无

Next: Clinical Application of YAN Xiaoping's Academic Thought of Preventive Treatment of Ankylosing Spondylitis

Analysis of Syndrome Differentiation and Treatment for Mycosis Fungoidesby Pathogenesis Theory of Cancerous Toxin
1.Department of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
2.The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210029, China
DOI：10.3969/j.issn.1673-7202.2021.17.021

扫描看全文

CHEN Xiaoli, YU Hui, KONG Xiangtu, et al. Analysis of Syndrome Differentiation and Treatment for Mycosis Fungoidesby Pathogenesis Theory of Cancerous Toxin[DB/OL].（2023-07-14）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails#10.3969/j.issn.1673-7202.2021.17.021
DOI：

CHEN Xiaoli, YU Hui, KONG Xiangtu, et al. Analysis of Syndrome Differentiation and Treatment for Mycosis Fungoidesby Pathogenesis Theory of Cancerous Toxin[DB/OL].（2023-07-14）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails#10.3969/j.issn.1673-7202.2021.17.021 DOI：

摘要

目的：,2,阐述国医大师周仲瑛教授癌毒病机理论指导下蕈样肉芽肿的病因病机及辨证治疗。,方法：,2,基于癌毒病机理论对蕈样肉芽肿的病因病机及辨证治疗进行系统阐释，回顾目前西医治疗的现状及难点，结合具体病案论述中西结合治疗的辨证思路。,结果：,2,对疾病早期患者采用以皮肤为靶向的局部治疗，中医辨证多为风热，以祛风清热、凉血解毒为主要治法。随着疾病的进展，采用全身系统治疗为主，病机属虚实夹杂，以益气养阴、凉血解毒为主要治法。,结论：,2,蕈样肉芽肿早期诊断困难，确诊主要依靠病理形态学及免疫组织化学。西药综合治疗效果不理想，中医治疗结合癌毒病机理论，分期分阶段紧扣核心病机，可有效控制症状，提高患者生命质量。

Abstract

Objective:,2,To narrate the etiology, pathogenesis and syndrome differentiation of the treatment of mycosis fungoides (MF) by ZHOU Zhongying (National TCM Master) 's pathogenesis theory of cancerous toxin.,Methods:,2,The pathogenesis and the treatment of MF were systematically expounded based on pathogenesis theory of cancerous toxin. We reviewed the current status and difficulties of Western medicine treatment, and discussed the syndrome differentiation thinking of integrated Chinese and Western medicine combined with specific cases.,Results:,2,Patients in early stages of MF were treated with skin-directed therapies. While the TCM syndrome differentiation was based on wind-heat type, and the therapeutic method was focused on wind-expelling, heat-clearing, cooling blood and detoxification. Systemic treatment is mainly used in the advanced stage of the disease. The pathogenesis be-longed to a mixture of deficiency and excess, and treated with supplementing qi, nourishing yin, cooling blood and detoxification.,Conclusion:,2, Early diagnosis of MF is difficult, and the diagnosis mainly depends on pathomorphology and immune tissue chemotherapy. The comprehensive treatment effect of Western medicine is not satisfactory. TCM treatment combined with the theory of cancer virus pathogenesis, closely focusing on the core pathogenesis in stages, can effectively control symptoms and improve the quality of life of patients.

关键词

癌毒病机理论蕈样肉芽肿辨证论治病因病机皮肤T细胞淋巴瘤中西医结合中医疗效

Keywords

Pathogenesis theory of cancerous toxinMycosis fungoidesSyndrome differentiationEtiology and pathogenesisCutaneous T-cell lymphomaChinese and Western medicineTraditional Chinese medicineEfficacy

references

Yeşiltaş YS, Hoşal MB, Yüksel MK, et al. Severe upper eyelidmass in a patient with mycosis fungoides[J]. Orbit, 2020, 39(2): 150-152.

Valipour A, Jäger M, Wu P, et al. Interventions formycosis fungoides[J]. Cochrane Database Syst Rev, 2020, 7(7): CD008946.

张永翠. NB-UVB联合外用卤米松乳膏治疗Ⅰ期蕈样肉芽肿的临床疗效分析[J]. 中国中西医结合皮肤性病学杂志, 2020, 19(1): 74-76.

Hristov AC, Tejasvi T, Wilcox RA. Mycosis fungoides and Sézary syndrome: 2019 update on diagnosis, risk-stratification, and management[J]. Am J Hematol, 2019, 94(9): 1027-1041.

Kamijo H, Miyagaki T. Mycosis fungoides and sézary syndrome: up-dates and review of current therapy[J]. Curr Treat Options Oncol, 2021, 22(2): 10.

Lovgren ML, Scarisbrick JJ. Update on skin directed therapies in mycosis fungoides[J]. Chin Clin Oncol, 2019, 8(1): 7.

吴岳桐, 陈茜, 曹国颖, 等. 皮肤T细胞淋巴瘤靶向治疗新药——mogamulizumab[J]. 临床药物治疗杂志, 2019, 17(7): 4-7.

王诗琪, 池诚, 刘洁, 等. 皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展[J]. 协和医学杂志, 2019, 10(2): 157-161.

Virmani P, Zain J, Rosen ST, et al. Hematopoietic stem cell transplant formycosis fungoides and sézary syndrome[J]. Dermatol Clin, 2015, 33(4): 807-818.

倪海雯, 朱篧, 郭立中. 周仲瑛癌毒学说在恶性淋巴瘤中的运用[J]. 安徽中医药大学学报, 2017, 36(5): 38-40.

程海波, 周仲瑛, 李柳, 等. 基于癌毒病机理论的中医肿瘤临床辨治体系探讨[J]. 中医杂志, 2015, 56(23): 1989-1992.

侯君, 夏婕, 李红毅, 等. 国医大师郖国维教授中医皮肤病临证思辨观浅析[J]. 四川中医, 2017, 35(6): 1-3.

Larocca C, Kupper T. Mycosis fungoides and sézary syndrome: An update[J]. Hematol Oncol Clin North Am, 2019, 33(1): 103-120.

Maguire A, Puelles J, Raboisson P, et al. Early-stage mycosis fungoides: epidemiology and prognosis[J]. Acta Derm Venereol, 2020, 100(1): adv00013.

王新, 樊娟丽, 杨改娥, 等. 窄谱中波紫外线联合干扰素治疗蕈样肉芽肿[J]. 中国药物与临床, 2019, 19(9): 1497-1498.

Nahidi Y, Meibodi NT, Ghazvini K, et al. Evaluation of the association between epstein-barr virus and mycosis fungoides[J]. Indian J Dermatol, 2015, 60(3): 321.

张筱雁, 王琳. 蕈样肉芽肿皮损中TOX蛋白的表达及其诊断价值评估[J]. 中华皮肤科杂志, 2020, 53(1): 13-16.

朱蒙燕, 虞闻仲, 王平, 等. 反射性共聚焦显微镜对早期蕈样肉芽肿定位诊断与疗效监测的研究[J]. 中华皮肤科杂志, 2020, 53(8): 634-639.

Hodak E, Amitay-Laish I. Mycosis fungoides: A great imitator[J]. Clin Dermatol, 2019, 37(3): 255-267.

Ito A, Sugita K, Ikeda A, et al. CD4/CD8 Double-negative mycosis fungoides: A case reportand literature review[J]. Yonago Acta Med, 2019, 62(1): 153-158.

周栩悦, 栾超, 陈崑, 等. 光疗在皮肤T细胞淋巴瘤中的应用进展[J]. 中华皮肤科杂志, 2020, 53(9): 764-767.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Experience of Professor WANG Junhong in the Treatment of Henoch-Schonlein Purpura

Professor Yang Zhibo Uses "Treatment in Accordance with Three Conditions" Theory to Treat the Experience of Alopecia

Analysis of HUA Baojin's Thought and Experience of "Tonifying Vital Qi and Regulating Qi" in Prevention and Treatment of Cancer

The Preventive Concept and Clinical Application of Collateral Disease Theory in the Treatment of Femoral Head Necrosis

WANG Xu's Clinical Experience on Treating Thyroid Nodules

Related Author

No data

Related Institution

Department of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine

Department of Traditional Chinese Medicine, Beijing Children's Hospital Affiliated to Capital Medical University

Department of Dermatology, The Second Hospital Affiliated to Hunan University of Chinese Medicine

Graduate School, Hunan University of Chinese Medicine

Beijing University of Chinese Medicine

⁰