In the treatment of plagues by ancient Chinese physicians,Bombyx batryticatus, was used quite frequently. Yang Lishan, a famous plague doctor in the Qing Dynasty, called ,Bombyx batryticatus, as "the holy medicine for febrile disease", and applied it in ,Shengjiang Powder, to treat many diseases. However, the modern Chinese medicine theory does not have an in-depth understanding of ,Bombyx batryticatus's, effectiveness in curing plague. The author started from the relevant ancient literature, and summarized the drug application, prescription, and effective cases of the ,Bombyx batryticatus,. We intended to explain that the ,Bombyx batryticatus, had the effect of treating fever, relieving exterior syndrome, eliminating phlegm and turbidity, and purging incubated diseases in TCM, and clarified its effective value in the treatment of plague, and the corresponding basis for syndrome differentiation, so as to provide clinical scholars for syndrome differentiation and treatment.