According to the basic pathogenesis of primary carcinoma of liver with liver stagnation and spleen deficiency as primary and syndrome of accumulation of blood stasis and toxin as secondary, Professor Cai Xiao-ping always uses the method of soothing liver and invigorating spleen and resolving blood stasis and removing toxin in clinical practice. He has established the basic formula for regulating liver and dispersing blockage for syndrome differentiation based on disease differentiation to modify flexibly. Professor Cai Xiao-ping points out that the common clinical syndrome types of primary carcinoma of liver include syndrome of liver stagnation and spleen deficiency, syndrome of accumulation of blood stasis and toxin, syndrome of accumulation of dampness and heat, and syndrome of liver-kidney yin deficiency. For syndrome of liver stagnation and spleen deficiency, the basic formula for regulating liver and dispersing blockage, Free Wanderer Powder, and Six Gentlemen Decoction are used alternately. For syndrome of accumulation of blood stasis and toxin which belongs to stagnated yang and toxin, the basic formula for regulating liver and dispersing blockage removing Xiangfu(,Rhizoma Cyperi,)and Honghua(,Flos Carthami,)while adding Chonglou(,Rhizoma Paridis,), Xiakucao(,Spica Prunellae,), Chansu(,Venenum Bufonis,), Yinchen(,Herba Artemisiae Scopariae,), Zhizi(,Fructus Gardeniae,)and Huashi(,Talcum,)can be used. For syndrome of accumulation of blood stasis and toxin which belongs to stagnated yin and toxin, the basic formula for regulating liver and dispersing blockage removing Huangqin(,Radix Scutellariae,)and Banzhilian(,Herba Scutellariae Barbatae,)and Zhebeimu(,Bulbus Fritillariae Thunbergii,)while adding Ganjiang(,Rhizoma Zingiberis,), Fuzi(,Radix Aconiti Lateralis Preparata,), Rougui(,Cortex Cinnamomi,)and Wuzhuyu(,Fructus Evodiae,)can be used. For syndrome of accumulation of dampness and heat, Four Substances Powder with Poria Plus Virgate Wormwood adding Chishao(,Radix Paeoniae Rubra,), stirfried Zhizi(,Fructus Gardeniae,)and Maidong(,Radix Ophiopogonis,)can be used. For syndrome of liver-kidney yin deficiency, Decoction for Nourishing Kidney and Clearing Liver can be mainly used. In terms of primary carcinoma of liver, Professor Cai advocates that the treatment should pay equal attention to Chinese and Western medicine, complement each other's advantages, and improve the clinical efficacy and the patients'quality of life.