The paper introduced the clinical experience of Professor Wu Xu, a well-known veteran traditional Chinese medicine doctor, in treating interstitial cystitis with" Tongdu Wenyang acupuncture". According to the etiology and pathogenesis of interstitial cystitis, Professor Wu proposed the therapeutic principles and methods under the guidance of the theory of" Tongdu Wenyang", that is, promoting the governor channel, harmonizing the resonance of qi, warming yang, coordinating the conception channel and the governor channel, dredging the belt channel, regulating the liver meridian, along with activating qi and blood. Meanwhile, the focus should be reached and the arrival of qi should be obtained with rectifying and regulating qi during needling. In addition, Professor Wu attached much importance in relaxing the mind, observing and maintaining the spirit, as well as giving psychological counseling during the process of needling, thus dredging the governor channel and yang meridians, harmonizing qi and blood, relieving symptoms and revoering the physiological function of bladder.