Chronic ulcerative colitis (CUC) is a colorectal non-specific inflammatory bowel disease whose etiology is not completely clear till now. Professor Lu Jingen argues that it is closely related to liver and spleen. Its main pathogenesis is dampness-heat in large intestine caused by stagnation of liver qi and spleen deficiency. He believes that its treatment should start from liver and spleen. The treatment principle is to invigorate spleen and disperse stagnated liver qi, clear heat and promote diuresis, and cool blood and arrest bleeding. The clinical joint use of Tongxie Fang and Baitouweng Decoction has a remarkable curative effect. The purpose of this article is to introduce Professor Lu Jingen's experience in using this prescription to treat CUC, so as to provide ideas for its treatment with traditional Chinese medicine.