The article introduces Professor Zhao Zhenchang's experience in treating chronic glomerulonephritis through invigorating qi and nourishing yin, dissipating turbidity and dredging collaterals. Professor Zhao Zhenchang believes that chronic glomerulonephritis is mostly caused by deficiency, dampness-turbidity and blood stasis, with deficiency of spleen and kidney as its root, deficiency of both qi and yin as its key pathogenesis, dampness-turbidity and blood stasis as the pathological products in the disease development, and an important promoting factor as well. In clinical practice, the above factors are often mingled with each other to cause diseases, resulting in a syndrome with deficiency of qi and yin, in combination with turbidity and blood stasis. Hence, it is thought that the treatment method should be mainly focused on benefiting qi and nourishing yin, dispelling turbidity and dredging collaterals. Professor Zhao Zhenchang's self-designed prescription "Zishen Xiezhuo Tongluo Decoction" proves to be remarkable in curative effect.