Professor LI Peixu, a famous traditional Chinese medicine professor, is "the fifth batch of famous traditional Chinese medicine", "the first batch of national excell 忍冬藤 ent clinical talents of traditional Chinese medicine" and "the tutor of inheriting the academic experience of national experts of traditional Chinese medicine". Since he has been a doctor for more than 40 years, he is good at using traditional Chinese medicine to treat chronic renal failure. According to the fact that the kidney is the organ related to water metabolism and controls the opening and closing of the bladder and the main five fluids. The kidney stores the essence, which is the innate foundation and the root of the five internal organs. It takes supplementing Qi and ascending Yang, resolving phlegm and reducing turbidity, removing blood stasis and dredging collaterals as the principle of prescriptions. When making the prescriptions, Professor LI pays attention to the drug taste, meridian tropism, rising and falling, identifying the location of the disease and using drugs according to the characteristics of the internal organs and meridians. Professor LI is especially fond of using drugs and selecting drugs which are mainly returning to the kidney meridians to promote water and dredging collaterals. According to the principle that the kidney governs Qi, it is good at strengthening and consolidating the foundation, restoring the rise and fall of Qi movement, benefiting the six Fu-organs and removing dampness and turbidity. According to the structural characteristics of long-term illness entering the collaterals, the renal collaterals are curved and narrow, and the rattan drugs are used well, and the effect very obvious. This paper summarizes 10 pairs of drugs commonly used by Professor LI, such as Rendongteng (Caulis Lonicerae Japonicae) and Luoshiteng (Caulis Trachelospermi), Difuzi (Fructus Kochiae) and Kushen (Radix Sophorae Flavescentis), Nyuzhenzi (Fructus Ligustri Lucidi)and Hanliancao (Eclipta chinensis), Tianma (Rhizoma Gastrodiae) and Gegen (Radix Puerariae Lobatae), Baizhu (Rhizoma Atractylodis Macrocephalae) and Cangzhu (Rhizoma Atractylodis), Huangqi (Radix Astragali) and Renshen (Radix Et Rhizoma Ginseng), Fangfeng (Radix Saposhnikoviae)and Chantui (Periostracum Cicadae), Dahuang (Radix Et Rhizoma Rhei) and Huanglian (Rhizoma Coptidis), Huoxiang (Herba Pogostemonis) and Zhuru (Caulis Bambusaein Taenia), Danggui (Radix Angelicae Sinensis) and Chuanxiong (Rhizoma Chuanxiong) and the clinical experience of application in order to provide some ideas for clinical colleagues.