Traditional Chinese medicine has great advantages in the treatment of chronic liver disease. In-depth study of the clinical experience in the diagnosis and treatment of chronic liver disease based on the classical theory of ,Treatise on Febrile Disease, is beneficial to the understanding and mastery of the classical theory and the clinical application of the classical prescription. Meanwhile, it inspires the clinical thinking of traditional Chinese medicine and provides new ideas for the diagnosis and treatment of chronic liver disease. This paper summarized Professor ZHOU Xiaoling's experience on distinguishing and treating chronic liver diseases from ,Treatise on Febrile Diseases·Jueyin Disease,. Professor ZHOU Xiaoling believes that in the later stage of the development of chronic liver disease, the diseases tend to be intermingled with heat and cold, imbalance of Yin and Yang and frequent death, which coincides with the pathogenesis of Jueyin disease. Professor ZHOU Xiaoling's long-term treatment of chronic liver disease under the guidance of the classical theory of ,Treatise on Febrile Diseases·Jueyin Disease, and prescriptions can often achieve good clinical efficacy, significantly reducing the symptoms of patients and adverse reactions, and significantly improving the quality of life. Principles of treatment should be to clear the upper and warm the lower, harmonize Yin and Yang, warm the meridian to spread cold, nourish blood and remove blood stasis. The representative prescriptions are Mahuang Shengma Decoction (麻黄升麻汤), Wenjing Decoction (温经汤), Danggui Sini Decoction (当归四逆汤), Sini Decoction (四逆汤), etc. The purpose of this paper is to elaborate on Professor ZHOU Xiaolin's experience in the pathogenesis differentiation and treatment of chronic liver disease from ,Treatise on Febrile Diseases,. Jueyin Disease, and to provide evidence for the two cases of Mahuang Shengma Decoc-tion and Wenjing Decoction.