The course of vessel impediment is difficult to heal, and it is easy to recur, which is called stubborn disease. Professor SI Guomin points out the pathogenesis of vessel impediment is due to unhealthy lifestyles of modern people, such as irregular life, improper work and rest, who are in a sub-health state, resulting in deficiency of Qi, insecurity of the interstices. In addition, overeating fat can damage the spleen and stomach, leading to the limbs lose nutrition and reduce immune function. Pathogenic Qi invades the body and stagnates in veins, causing vessel impediment. The disease is located in the vessels, and Yang deficiency and blood weakness are the key to the pathogenesis. From the perspective of Qi and blood, professor SI Guomin differentiates syndromes based on three points of deficiency, heat and blood stasis. The treatment principle is to warm Yang, enrich the blood and dredge collaterals. Professor SI attaches great importance to the treatment methods of taking care of spleen and stomach, clearing heat and cooling blood, and promoting blood circulation to remove blood stasis. Huangqi Guizhi Wuwu Decoction (黄芪桂枝五物汤) is selected as the basic prescription in the treatment, with Huangqi (Radix Astragali), Guizhi (Ramulus Cinnamomi), Shaoyao (Radix Paeoniae Alba), Danggui (Radix Angelicae Sinensis) and Zhimu (Rhizoma Anemarrhenae) as the main medicines. The treatment is to invigorate Yang and Qi, benefit Qi and harmonize stomach, resolving Bi syndrome and dredging collaterals, adjusting the drugs according to the patients′condition. Professor SI pays attention to the role of invigorating Qi in clinical practice, and uses Huangqi (Radix Astragali) wisely and in larger dosages. Professor SI believes that Professor SI is active in the process of supplementing Qi, reaching both inside and outside. This article expounded the syndrome differentiation thoughts and medication characteristics of Professor SI in the diagnosis and treatment of the disease, and introduced a case in detail by using Huangqi Guizhi Wuwu Decoction, in order to provide experience and ideas for clinical workers.