The paper summarizes chief physician, Wang Zili,’,s, experience in treating difficult and miscellaneous diseases in various departments with classical prescription flexibly from four aspects:modified, Guizhi Tang, in treating head and body pain caused by external factors,unexplained fever,postpartum joint pain,hyperhidrosis and palmar hyperhidrosis,the clinical application of, Guizhi Tang, mainly takes the disharmony of, Qi, and blood,the imbalance of nutrient, Qi, and defensive, Qi,the disharmony of, Yin, and, Yang, as the pathogenesis,regulating nutrient, Qi, and defensive, Qi,adjusting and tonifying, Qi, and blood,balancing, Yin, and, Yang, as the key.