Summary of case history,　Patient, female, 56 years old. On June 10, 2021, she sought medical attention due to dry eyes and mouth for over a year. She was diagnosed with dry eye more than a year ago and referred to the Department of Rheumatology and Immunology. Due to significant elevation of ALP and GGT, as well as positive anti SSA and AMA-M2 in autoantibodies, she was diagnosed with Sjogren's syndrome and primary biliary cholangitis, and was treated with a standard dose of ursodeoxycholic acid capsule 750mg/d orally to improve cholestasis. During the medication period, her intermittent follow-up ALP and GGT were consistently higher than normal. It was considered that the UDCA response was poor, so she sought medical attention at our hospital. After liver biopsy confirmed the diagnosis of PBC with disappearance of bile ducts, she was treated with a combination of traditional Chinese and western medicine. Symptoms and signs: Lack of energy, pale complexion with swarthy black spots, red cheekbones, thin and tired body, weak waist and legs, heart palpitations, restlessness and lack of sleep, slightly bitter dry mouth, dry eyes, and occasional tinnitus. Poor appetite, dry stools, and short voidings of scant urine. The tongue was dull red, with few cracks on the tongue coating,and the pulse was thin and fast.,TCM diagnosis,　Consumptive disease. Liver and kidney Yin deficiency syndrome.,Western medicine diagnosis,　Primary biliary cholangitis (Vanishing type of bile duct) .,Therapeutic methods,　Traditional Chinese medicine treatment: Using Professor GUO Jianchun's theory of "visceral symptoms-disease-syndrome" in the treatment of PBC, based on the concept of "liver collaterals", the method of consistently decocting, adding and subtracting was applied throughout the entire process. According to the evolution of symptoms, methods such as nourishing the kidney and filling the essence, softening the liver and stomach, nourishing blood and promoting blood circulation, dispersing wind and relieving itching, soothing the liver and stomach, and promoting blood circulation and resolving fibrosis were applied. Western medicine treatment: long-term oral administration of ursodeoxycholic acid capsules (250 mg/tablet) 3 tablets/day.,Clinical outcomes,　After treatment with a combination of traditional Chinese and western medicine, the patient's symptoms such as dry mouth, dry eyes, and fatigue improved. ALP and GGT indicators gradually decreased, and liver histology improved.