A case of Henoch-Schonlein Purpura Nephritis Treated by Professor Lei Genping with the Therapy Combined of Chinese and Western Medicine
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1.The First Clinical Medical College, Shaanxi University of Traditional Chinese Medicine,Xianyang 712000
2.Department of Nephrology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000
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LIU Li, XIE Jiongdong, LEI Genping. A case of Henoch-Schonlein Purpura Nephritis Treated by Professor Lei Genping with the Therapy Combined of Chinese and Western Medicine[DB/OL].(2023-10-31)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43394544&Fpath=home&index=0
病史摘要,2,患儿张某,女,5岁,2019年3月26日初诊。主诉为“双下肢紫癜1个半月余”。2019年2月5日患儿无明显诱因出现双下肢对称性暗红色皮疹,就诊于当地医院,诊断为“过敏性紫癜”,经治疗(具体不详)后,皮疹减退,期间查尿常规正常。2019年2月11日至2019年2月20日期间反复查尿常规:蛋白+~3+,隐血±~3+。患儿于2019年2月20日无明显诱因再次出现双足皮疹,性质同前,诊于西安市儿童医院,诊断为“过敏性紫癜、紫癜性肾炎”,建议行肾脏穿刺检查明确病理类型,患儿家属拒绝,于2月25日开始口服激素强的松片(剂量:15 mg/次,3次/日)抑制免疫反应,予芦丁片(20 mg/次,2次/日)、双嘧达莫片(25 mg/次,3次/日)、卡托普利片(8.33 mg/次,1次/日)、钙尔奇D(1片/次,1次/日)辅助治疗。期间规律服药,症状稍好转。3月23日无诱因患儿右下肢、足背再次出现皮疹,复查尿常规:蛋白质2+,隐血+-,红细胞84.7μl;肝功、肾功:总蛋白51.9 g/L,白蛋白29.2 g/L,肌酐28 μmol/L,β2-微球蛋白0.93 mg/L;尿肌酐154 μmol/L,尿微量白蛋白819.8 mg/L,微量白蛋白/肌酐532.34 mg/mmoL,3月24日查24小时尿总蛋白测定为1473 mg。3月26日为求中医治疗,特来陕西中医药大学附属医院名医馆就诊。刻下症见:神志清,双下肢数个针尖样大小的暗红色皮疹,与皮肤相平,压之不褪色,自述双手皮肤有痒感,夜间汗出明显,晨起口干欲饮,腹痛,伴全身乏困。平素怕热,纳食差,睡眠可,小便量正常,色黄、泡沫多,大便不成形,1-2次/天。舌偏红,苔薄白,脉濡。初诊时激素已规律服用4周(剂量:15 mg,每天三次),未开始减量,继续服用双嘧达莫片及钙尔奇D。中医诊断 紫斑(脾肾亏损,气阴两伤,湿热瘀结证)西医诊断 过敏性紫癜性肾炎干预措施 中医治法:培补脾肾,益气养阴,利湿活血。选用芪地固肾方联合抗敏除湿汤加减。西医治法:患儿自2019年2月25日开始口服激素强的松片(剂量:15 mg/次,3次/日)治疗,足量应用8周,2019年4月24日开始激素移行减量,于5月14日、5月28日、6月5日、6月11日、6月15日逐次减量,6月17日停用激素。予芦丁片(20 mg/次,2次/日)、双嘧达莫片(25 mg/次,3次/日)、卡托普利片(8.33 mg/次,1次/日)、钙尔奇D(1片/次,1次/日)对症治疗。疗效转归 该患儿于我处加服中药1周后双下肢皮疹消失,复查尿常规示蛋白、隐血、红细胞指标均好转,24h尿总蛋白较前下降,提示本次治疗有效,在主方不变的基础上随症调整用药,坚持服药10月余,病情稳定,患儿尿中红细胞基本控制在0~100 μ/L之间,24h尿蛋白基本控制在50~200 mg之间,期间患儿改变挑食、偏食等不良饮食习惯,避免劳累、感染等加重肾脏损害,皮肤紫癜、胃肠道症状及尿蛋白等症状均明显缓解,疗效肯定。
Summary of case history, The child patient Zhang, female, 5 years old, was first diagnosed on March 26, 2019. The chief complaint was "purpura on both lower extremities over a month and a half ".On February 5, 2019, the child patient broken out in a symmetrical dark red rash on both lower extremities without obvious inducement, and was diagnosed as "Henoch-Schonlein purpura" in a local hospital. After treatment (the details are unknown), the rash dissipated, during this period, her routine urine examination was normal.From February 11, 2019 to February 20, 2019, the child repeated routine urine examination: protein +~3+, occult blood ±~3+. On February 20, 2019, the child patient broken out in a rash on both feet again without obvious inducement, with the same nature as before, and was diagnosed as "Henoch-Schonlein purpura and purpura nephritis" in Xi 'an Children's Hospital. The doctor suggested perform kidney puncture to confirm the pathological type, but declined by the child patient's family..On February 25, the child patient was given oral prednisone tablets (15 mg/time,3 times/day) to suppress the immune response, and rutin tablets (20 mg/time, 2 times/day), dipyridamole tablets (25 mg/time,3 times/day), captopril tablets (8.33 mg/time, 1 time/day), Caltrate With Vitamin D Tablets (1 tablet/time, 1 time/day) were given as adjuvant therapy.During the period, the child patient took medicine regularly, and the symptoms improved slightly. On March 23, the child patient broken out in a rash on the right lower extremity and double dorsalis pedis without inducement. Routine urine examination showed protein 2+, occult blood ±, urinary red blood cell quantification 84.7 /ul. Liver and renal function test: total protein(TP) 51.9g/L, albumin(ALB) 29.2 g/L, serum creatinine 28 umol/L, β2-microglobulin 0.93 mg/L; Urinary creatinine was 154 umol/L, urine microalbumin 819.8mg/L, and urine microalbumin/urine creatinine was 532.34 mg/mmol. On March 24, 24-hour urinary protein quantity 1473 mg .On March 26, the patient came to the Famous Doctor Pavilion of the Hospital of Shaanxi University of Traditional Chinese Medicine to seek TCM treatment. Symptoms: conscious mind, there are several needle-like dark red rash on both lower extremities, flat with the skin , pressure on the rash and it doesn't fade. the child patient own words: skin itch of both hands, easy to sweat at night, dry mouth to drink in the morning, abdominal pain, accompanied by general fatigue. Usually afraid of heat, poor food intake, normal sleeping, normal urine volume, yellow urine, a large foam in the urine, shapeless stool once or twice a day. The tongue is red, the moss is thin and white, and the pulse is moisten. At first diagnosis, the child patient, had been taking prednisone regularly for 4 weeks (15mg/ time,3 times/day), and did not start to reduce the dose, the child patient continued to take dipyridamole tablets and Caltrate With Vitamin D Tablets.,TCM diagnosis, Suggillation (Deficiency of spleen and kidney,qi and yin deficiency,damp heat and blood stasis obstruction),Western medicine diagnosis, Henoch-Schonlein Purpura Nephritis,Therapeutic methods, TCM treatment: nourishing spleen and kidney, nourishing qi and Yin, invigorate dampness and promote blood circulation. Qidi Gushen recipe combined with anti-sensitization dehumidification decoction.Western medicine treatment: The child patient adequate used of prednisone tablets ( 15mg/ time, 3 times/day) since February 25, 2019, lasted for 8 weeks. On April 24, 2019, began to reduce the dose of prednisone tablets , and reduced successively on May 14, May 28, June 5, June 11, and June 15, on June 17 it was reduced to a halt. Giving rutin tablets (20mg/ time, twice/day), dipyridamole tablets (25mg/ time, 3 times/day), captopril tablets (8.33mg/ time, once/day), Caltrate With Vitamin D Tablets (1 tablet/time, once/day)to treat the symptoms.,Clinical outcomes, The patient was treated with oral TCM decoction in our department, and a week later, the rash on both lower extremities disappeared. .Reviewing routine urine examination showed that the indicators of protein, occult blood and urinary red blood cell quantification were all improved, and the 24-hour urinary protein quantification decreased.Above results were suggesting this treatment was effective. On the basis of the main prescription unchanged, the decoction was adjusted according to the disease, and the decoction was kept taking for more than 10 months.The child patient's condition was stable, and urinary red blood cell quantification was basically controlled between 0-100 /ul, and the 24-hour urine protein quantification was basically controlled between 50-200 mg. In the mean time, the child patient changed her unhealthy diet such as picky eating and partiality for a particular kind of food, and avoided aggravating renal damage such as fatigue and infection. The symptoms such as skin purpura, gastrointestinal symptoms and urinary protein were relieved obviously.It shows that the curative effect is significant in this treatment.
过敏性紫癜性肾炎芪地固肾方抗敏除湿汤桂枝茯苓丸
Henoch Schonlein Purpura NephritisQidi Gushen recipeAnti-sensitization dehumidification decoctionGuizhi Fuling Bolus
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