A Case of Failed Biologic Intervention for Ankylosing Spondylitis Differentiated and Treated by HE Xiaojin

XIE Minzhu; LIU Yinxin; XIE Guoqian; HE Xiaojin

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A Case of Failed Biologic Intervention for Ankylosing Spondylitis Differentiated and Treated by HE Xiaojin

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A Case of Failed Biologic Intervention for Ankylosing Spondylitis Differentiated and Treated by HE Xiaojin
1.Department of Rheumatology,The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China
2.Department of Respiratory,Tianjin Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin 300450, China
DOI：

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XIE Minzhu, LIU Yinxin, XIE Guoqian, et al. A Case of Failed Biologic Intervention for Ankylosing Spondylitis Differentiated and Treated by HE Xiaojin[DB/OL].（2023-10-27）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052697&Fpath=home&index=0
DOI：

XIE Minzhu, LIU Yinxin, XIE Guoqian, et al. A Case of Failed Biologic Intervention for Ankylosing Spondylitis Differentiated and Treated by HE Xiaojin[DB/OL].（2023-10-27）[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43052697&Fpath=home&index=0 DOI：

摘要

病史摘要,2,患者乐某，男，23岁，2018年6月21日因“腰背部僵痛半年，加重2月”求诊。患者来诊时已确诊为“强直性脊柱炎”，并已在当地三甲医院行生物制剂治疗（注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白25mg皮下注射每周2次），效果不显，疼痛僵硬等症状仍进行性加重。患者考虑长期生物制剂治疗存在诱发感染、增加恶性疾病发生率及影响其他脏器功能等弊端，遂放弃西医治疗，经人介绍至何晓瑾教授门诊寻求中医治疗。何师以温肾强督，化痰逐瘀，通络止痛为大法，从肝脾肾三脏论治，收效颇丰，患者腰背疼痛从程度减轻到频次降低再到基本消失，何师从根本上改变了患者体质，实现了临床缓解。中医诊断　大偻肾虚督亏，痰瘀痹阻西医诊断　强直性脊柱炎干预措施　以温肾强督，化痰逐瘀，通络止痛之法拟方论治疗效转归　临床缓解

Abstract

Summary of case history,　Patient Le, male, 23 years old, sought medical attention on June 21, 2018, for "stiffness and pain in the lower back for six months, aggravated for two months". The patient had been diagnosed with "ankylosing spondylitis" at the time of consultation and had been treated with biologics (Recombinant human type Ⅱ tumor necrosis factor receptor-antibody fusion protein for injection 25mg subcutaneously twice a week) at a local tertiary care hospital, but the effect was not significant and the pain and stiffness continued to worsen progressively. The patient considered that long-term biologic treatment has the disadvantages of inducing infection, increasing the incidence of malignant disease, and affecting the function of other organs, so he gave up Western medical treatment and was referred to Professor He's clinic for Chinese medicine treatment. The patient's lower back pain was reduced from the degree to the frequency to the basic disappearance. Professor He fundamentally changed the patient's constitution and achieved clinical remission.TCM diagnosis　Dyphosis, Kidney deficiency and Du deficiency, Paralysis with phlegm and stagnation syndromeDiagnosis　Ankylosing spondylitisTherapeutic methods　To warm the kidneys and strengthen the Du, resolve phlegm and remove blood stasis, and relieve pain for the treatment of the proposed prescription.Clinical outcomes　clinical remission.

关键词

强直性脊柱炎大偻

Keywords

Ankylosing spondylitisDyphosis

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