Summary of case history,　The patient, a 57-year-old male, came to the clinic mainly because of "7 years of elevated blood sugar, elevated serum creatinine for more than 10 months, and edema of both lower extremities for more than 1 month." The patient developed thirst, polydipsia, and polyuria in 2013, and was diagnosed with type 2 diabetes at Tongren Huaxia Hospital. Diabetic retinopathy was diagnosed in 2018. In August 2019, the physical examination showed Scr 130 umol/L(46～104 umol/L), and was diagnosed as "diabetic kidney disease, Chronic kidney disease stage 3" at the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine. Control can be. On December 27, 2019, he went to the outpatient department of Shandong Provincial Hospital of Integrated Traditional Chinese and Western Medicine. Blood and biochemical tests: Scr 125.5 umol/L. He was treated with traditional Chinese medicine for nourishing qi, nourishing yin, clearing the intestines and removing turbidity for more than 4 months, and the Scr ranged from 130 to 150 umol/L. On May 8, 2020, due to the edema of both lower extremities accompanied by increased foam after traditional Chinese medicine, and it was considered that the efficacy was not good, and the treatment was changed to the the herbal medicines of clearing the intestines, removing turbidity, and Eliminate evil and dampness for nearly 1 month, and his condition did not improve. On June 10, 2020, blood biochemical examination: Scr 158.5 umol/L, for further treatment, he came to me for diagnosis and treatment. Current symptoms: concave edema of both lower extremities, aggravated during activity, relieved after rest, no obvious discomfort, good appetite, poor sleep, difficulty falling asleep, light sleep and easy awakening. Foamy urination, nocturnal urination 2 to 4 times, and stool. The tongue is red and thin, with a slightly yellow and greasy coating, the middle part of the pulse is like a qin string, and the upper and lower parts are weak.,TCM diagnosis,　diabetic kidney disease(deficiency of kidney essence, water, dampness, blood stasis, heat pathogenic obstruction of kidney collaterals syndrome),Western medicine diagnosis,　chronic kidney disease stage 3; diabetic kidney disease; type 2 diabetes; diabetic retinopathy; hypertension grade 3 very high risk group,Therapeutic methods,　In terms of traditional Chinese medicine: the treatment is based on Filling kidney essence, clearing heat, diuretic water, removing dampness, removing blood stasis to dredging collaterals; in terms of western medicine: the programs for lowering blood sugar, lowering blood pressure and correcting anemia remain unchanged.,Clinical outcomes,　After three and a half months of traditional Chinese medicine treatment, the edema of both lower extremities of the patient disappeared, the urination foam was significantly reduced compared with before, and the sleep was improved. Scr decreased from158.5 umol/L at the time of visiting to the normal range (serum creatinine85.8 umol/L), UREA9.93 mmol/L decreased to8.32 mmol/L, cystatin C decreased from 3.24 mg/L to 1.80 mg/L, β2-MG decreased from 5.38 mg/L to 4.76 mg/L, and urinary protein decreased from 2+ to +-. On July 8, 2022, the blood biochemical examination showed: UREA 8.45 mmol/L, Scr 97.2 umol/L, UA 357 umol/L, Cysc 1.63 mg/L, β2-MG 5.58 mg/L; urine routine: PRO +-.