Summary of case history,　The patient, a 54-year-old female, was hospitalized in the Department of Shenzhen Hospital of Traditional Chinese Medicine on September 23, 2021 because of "Cough, asthma for more than 2 months, aggravated with fever for 4 days". On admission, the chest CT showed: diffuse interstitial inflammation in both lungs. After admission, the blood anti-SSA / Ro52 was positive while the antibody idiopathic inflammatory myopathy spectrum 1 (item 17) pointed out: EJ antibody +, Ro52 antibody +++. what's more, the electron bronchoscopy lung biopsy (TBLB) pathology showed: tissue changes consistent with connective tissue-associated interstitial pneumonia (non-specific interstitial pneumonia with organic pneumonitis). She received anti-infection, anti-inflammation, anti-asthma, immunosuppression treatments, immunoregulation and TCM syndrome differentiation and treatment for 18 days, and her symptoms were slightly improved, but her asthma was still obvious after exercise. Chest CT reviewed on October 5,2021: interstitial inflammation in both lungs was slightly absorbed than before. In order to seek further diagnosis and treatment of Chinese and western medicine, then asked for treatment in Xie Wei chief physician. The four methods of diagnosis for the first time: mental fatigue, obvious asthma after activity and bending, chest tightness, fatigue, cough, occasional cough of white sticky phlegm, dry and thirst, without fever with chilliness, easy sweating, poor appetite and sleep, loose stools, good urination.The tongue is dark red, the moss is yellow and greasy, and the pulse condition is string and slick.,TCM diagnosis,　Atrophic lung disease (syndrome of asthenia of pulmonosplenic qi, phlegm and blood stasis obstructing lung).,Western medicine diagnosis,　Interstitial lung disease related to antisynthetase syndrome(EJ antibody +, Ro52 antibody +).,Therapeutic methods,　In terms of traditional Chinese medicine, combining with the basic pathogenesis about atrophic lung disease of "Deficiency of Qi, phlegm and blood stasis" that summarized by Xie Wei chief physician, the intervention of traditional Chinese medicine was given as the basic method of "tonify the spleen and lung, invigorating qi and removing phlegm, promoting lung and removing blood stasis, vein relaxing and relieving asthma". Combined with the clinical data from four methods of diagnosis, the Feixianfang was used as the main prescription and adjusted according to the syndrome differentiation. At the same time, the conventional western medicine was used, like anti-inflammatory, immune suppression programs and so on.,Clinical outcomes,　After comprehensive diagnosis and treatment of Chinese and western medicine, the patient has no obvious asthma, cough and sputum, and can return to normal work. In November, 2021, April, 2022 and August, 2022, the chest CT showed that double pneumonia was significantly absorbed, and methylprednisolone was gradually reduced up to 12mg. Moreover, rheumatology department recommend triptoldoside, cyclophosphamide as immunodepressive treatment. At the same times, traditional Chinese medicine was changed to pills for long-term treatment, and the perceived quality of life was significantly improved, without recurrence.