Summary of case history ,The elderly male patient has a history of "hypertension". Who was admitted to hospital because of "right flank skin herpes with pain for 8 days and no urine for 2 days". The patient had no obvious inducement to develop herpes zoster in the right flank 8 days before admission, accompanied by persistent burning pain. The patient was diagnosed as "herpes zoster" in the external hospital, and was treated with "acyclovir". There was no urine 2 days before admission, and the blood creatinine increased progressively. On admission, the patient complained of skin pain and fatigue in the right flank, chest tightness and shortness of breath after activities, paroxysmal pain around the umbilicus, obvious after eating, accompanied by nausea and vomiting, cough with little white sticky sputum, no chills and fever, poor appetite, normal sleep and stool, but no urine. Physical examination: body temperature: 36.3 ℃, pulse: 101/min, respiration: 18/min, blood pressure: 207/87 mmHg. Scattered red skin lesions can be seen in the back, right armpit and right inguinal area, a small amount of wet rales can be heard in both lungs, the abdomen is soft, the whole abdomen is scattered with tenderness, no rebound pain, no percussion pain, no mobile dullness and no edema in the liver and kidney areas. The tongue is dark red, the moss is white and greasy, and the pulse is slippery.,TCM diagnosis ,kidney failure (spleen and kidney qi deficiency and dampness turbidity syndrome),Western medicine diagnosis ,acute tubular necrosis; herpes zoster; hypertension grade 3 (extremely high risk); pulmonary infection,Therapeutic methods ,After admission, actively finish relevant examinations, give anti infection、control blood pressure、fluid infusion and continuous blood purification treatment (CRRT) twice. The traditional Chinese medicine treatment is to strengthen the spleen and kidney, remove dampness and reduce turbidity, we selected Sijunzi Decoction and Liuwei Dihuang Decoction, supplemented by colon dialysis with Shiwei kidney toxin clear liquid to remove toxins and reduce turbidity. The renal pathology is "Renal tubular necrosis" Witch is considered acute renal injury caused by acyclovir in combination with the medical history, stop CRRT treatment and continue anti infection、fluid infusion and traditional Chinese medicine treatment.,Clinical outcomes ,The urine volume gradually returned to normal, and the blood creatinine gradually decreased to basically normal before discharge.