Summary of case history, The patient was admitted to our hospital mainly because of "Edema, fatigue, foamy urine for 1 year, serum creatinine increased for 1 day". The patient began to develop recurrent edema of both lower limbs, fatigue and foamy urine in August 2020, which did not pay attention to, diagnosis and treatment. On August 4, 2021, the patient was admitted to the Qingcheng Hospital because of pain in the left lower abdomen and groin. The blood urea nitrogen was 19.97 mmol/L, creatinine 423 umol/L, uric acid 555.3 umol/L, C-reactive protein 95.5 mg/L, and β2-microglobulin 14.14 mg/L.Color ultrasound of the groin showed a left inguinal hernia. Physical examination:Temperature: 36.2℃ Pulse: 109 bpm Respiration: 21 bpm BP: 230/170 mmhg. Amlodipine besylate was administered for hypertension. He was admitted to our hospital on August 4, 2021. The symptoms include fatigue, waist pain, headache, no nausea and vomiting, no rash, no arthralgia, low fever, cough, cough a small amount of white sputum, normal appetite, poor sleep, normal stool, normal urine volume, foam, nocturia 3 times, reddish tongue, thin yellow and cracked tongue coating, sublingual veins purple and dark, thin and fast pulse. Both lower limbs are not swollen.,TCM diagnosis, edema ;chronic renal failure,Syndrome diagnosis, spleen-kidney qi deficiency, stasis-heat injury Yin syndrome.,Western medicine diagnosis, chronic nephritis;acute-on-chronic kidney disease;grade 4. hypertension (very high risk group) ;pneumonia;left inguinal hernia.,Therapeutic methods, Intervention measures are mainly given to traditional Chinese medicine decoction for replenishing spleen and kidney and nourishing yin, clearing heat and activating blood circulation. Western medicine was given to nifedipine controlled-release tablets, metoprolol tartrate, clonidine, terazosin to control blood pressure, anti-infection, reduce uric acid, improve anemia and other symptomatic treatment. ,Clinical outcomes, The patient persisted in taking traditional Chinese medicine treatment. 2022-02-23 urine routine: protein-g/L, occult blood-Cells/ul, hemoglobin 120 g/L, urea nitrogen 12.07 mmol/L albumin, creatinine 147.16 umol/L, microalbuminuria 31.30 mg/L, 24-hour urinary protein 0.18 g (1800 mL). Since then, the patient has repeatedly reexamined urinary protein-, occult blood-, and serum creatinine around 140 umol/L.