The optic nerve disease is one of the most common eye diseases in the field of neuro-ophthalmic diseases, which can lead to severe visual impairment and even blindness. Professor Wei Qiping has been engaged in ophthalmology for more than 40 years, and has rich clinical experience in the diagnosis and treatment of optic nerve diseases. Professor Wei believes that the treatment of optic nerve diseases should be based on regulating the liver. This paper introduces Professor Wei’s experience in treating optic neuritis, Leber’s hereditary optic neuropathy, ischemic optic neuropathy and optic atrophy from the perspective of the liver, and expounds it in combination with clinical cases.