[DB/OL].(2023-02-27)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=27362810&Fpath=home&index=0
药物相关性颌骨坏死是双膦酸盐类药物潜在的严重不良反应,以坏死骨暴露、软组织脓肿至出现瘘管和弥漫性疼痛为主要临床表现。双膦酸盐类药物作为恶性肿瘤骨转移一线治疗用药,近年由其引发的药物相关颌骨坏死发生率有所升高,而临床缺乏有效治疗手段,值得引起关注。根据本病临床表现,与中医古籍中“骨槽风”相似,目前尚缺少中医药论治该病的临床报道。介绍1例乳腺癌骨转移患者应用唑来膦酸后导致下颌骨坏死,经外科手术及抗感染等治疗后复发加重的病例,通过中医辨病辨证相结合,考虑为正气无力托毒外出,导致败骨内留,局部毒热瘀邪相搏结,治以托里透脓、清热解毒、活血止痛,处方以仙方活命饮为主加减化裁,经5个月的治疗使患者局部症状消失,坏死骨脱落,破溃处愈合,取得了良好疗效。希望借此病例为药物相关性颌骨坏死的治疗提供思路。
下颌骨坏死双膦酸盐骨槽风中医药疗法仙方活命饮【适合阅读专业】 肿瘤
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